INPP5D [The Human Chemical-Genetic Interaction Map Project]

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======= INPP5D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INPP5D
  * **<color #00a2e8>Official Name</color>**: inositol polyphosphate-5-phosphatase D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3635|3635]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92835|Q92835]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INPP5D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INPP5D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601582|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. {ECO:0000269|PubMed:12421919, ECO:0000269|PubMed:16682172}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of neutrophil differentiation|
|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|
|regulation of neutrophil differentiation|
|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|
|negative regulation of interleukin-6 biosynthetic process|
|inositol-polyphosphate 5-phosphatase activity|
|inositol-1,4,5-trisphosphate 5-phosphatase activity|
|negative regulation of monocyte differentiation|
|negative regulation of granulocyte differentiation|
|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|
|positive regulation of B cell differentiation|
|negative regulation of bone resorption|
|regulation of granulocyte differentiation|
|negative regulation of bone remodeling|
|negative regulation of B cell proliferation|
|determination of adult lifespan|
|regulation of monocyte differentiation|
|negative regulation of tissue remodeling|
|phosphatidylinositol dephosphorylation|
|regulation of interleukin-6 biosynthetic process|
|negative regulation of osteoclast differentiation|
|regulation of B cell differentiation|
|positive regulation of erythrocyte differentiation|
|negative regulation of B cell activation|
|negative regulation of cytokine biosynthetic process|
|phospholipid dephosphorylation|
|multicellular organism aging|
|regulation of bone resorption|
|negative regulation of interleukin-6 production|
|negative regulation of myeloid leukocyte differentiation|
|regulation of erythrocyte differentiation|
|regulation of bone remodeling|
|inositol phosphate metabolic process|
|regulation of B cell proliferation|
|regulation of osteoclast differentiation|
|regulation of tissue remodeling|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of myeloid cell differentiation|
|negative regulation of leukocyte proliferation|
|positive regulation of myeloid cell differentiation|
|positive regulation of lymphocyte differentiation|
|negative regulation of leukocyte differentiation|
|regulation of cytokine biosynthetic process|
|phosphatidylinositol biosynthetic process|
|polyol metabolic process|
|regulation of myeloid leukocyte differentiation|
|SH3 domain binding|
|negative regulation of hemopoiesis|
|regulation of interleukin-6 production|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|positive regulation of B cell activation|
|phosphatidylinositol metabolic process|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|T cell receptor signaling pathway|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|lipid modification|
|glycerophospholipid biosynthetic process|
|immunoglobulin mediated immune response|
|regulation of B cell activation|
|B cell mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|glycerolipid biosynthetic process|
|regulation of leukocyte proliferation|
|membrane raft|
|regulation of myeloid cell differentiation|
|phospholipid biosynthetic process|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|aging|
|antigen receptor-mediated signaling pathway|
|glycerophospholipid metabolic process|
|dephosphorylation|
|alcohol metabolic process|
|positive regulation of lymphocyte activation|
|cytoskeleton|
|phospholipid metabolic process|
|leukocyte migration|
|glycerolipid metabolic process|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|organic hydroxy compound metabolic process|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|organophosphate biosynthetic process|
|immune response-activating signal transduction|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|leukocyte mediated immunity|
|positive regulation of immune response|
|organophosphate metabolic process|
|apoptotic process|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|cell migration|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|programmed cell death|
|cell motility|
|localization of cell|
|cell death|
|immune effector process|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INPP5D Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>