INSIG1 [The Human Chemical-Genetic Interaction Map Project]

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======= INSIG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INSIG1
  * **<color #00a2e8>Official Name</color>**: insulin induced gene 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3638|3638]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15503|O15503]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INSIG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INSIG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602055|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. {ECO:0000269|PubMed:12202038, ECO:0000269|PubMed:12535518, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16399501, ECO:0000269|PubMed:16606821}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|INSIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cargo loading into COPII-coated vesicle|
|SREBP-SCAP complex retention in endoplasmic reticulum|
|regulation of cargo loading into COPII-coated vesicle|
|negative regulation of SREBP signaling pathway|
|SREBP-SCAP-Insig complex|
|regulation of SREBP signaling pathway|
|SREBP signaling pathway|
|cellular response to sterol depletion|
|cranial suture morphogenesis|
|negative regulation of protein exit from endoplasmic reticulum|
|response to sterol depletion|
|maintenance of protein localization in endoplasmic reticulum|
|negative regulation of fatty acid biosynthetic process|
|regulation of ER to Golgi vesicle-mediated transport|
|craniofacial suture morphogenesis|
|middle ear morphogenesis|
|cellular response to sterol|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|negative regulation of fatty acid metabolic process|
|regulation of protein exit from endoplasmic reticulum|
|response to sterol|
|ER-nucleus signaling pathway|
|maintenance of protein localization in organelle|
|negative regulation of intracellular protein transport|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of fatty acid biosynthetic process|
|negative regulation of fat cell differentiation|
|sterol biosynthetic process|
|negative regulation of lipid biosynthetic process|
|negative regulation of intracellular transport|
|cranial skeletal system development|
|triglyceride metabolic process|
|maintenance of protein location in cell|
|cholesterol homeostasis|
|sterol homeostasis|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|regulation of steroid biosynthetic process|
|roof of mouth development|
|negative regulation of small molecule metabolic process|
|maintenance of location in cell|
|inner ear morphogenesis|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|maintenance of protein location|
|alcohol biosynthetic process|
|negative regulation of cellular protein localization|
|bone morphogenesis|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|ear morphogenesis|
|regulation of fat cell differentiation|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|protein localization to endoplasmic reticulum|
|maintenance of location|
|regulation of cellular ketone metabolic process|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|inner ear development|
|bone development|
|ear development|
|regulation of intracellular protein transport|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|steroid metabolic process|
|embryonic organ morphogenesis|
|alcohol metabolic process|
|regulation of intracellular transport|
|negative regulation of organelle organization|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|embryonic organ development|
|organic hydroxy compound metabolic process|
|negative regulation of transport|
|skeletal system development|
|cellular response to lipid|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|sensory organ development|
|regulation of vesicle-mediated transport|
|embryonic morphogenesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|response to lipid|
|regulation of cellular localization|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|embryo development|
|endoplasmic reticulum|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.98|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.7|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.09|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.19|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.28|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.98|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.06|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trappc10|TRAPPC10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2625
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INSIG1 Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>