INTS10 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS10
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55174|55174]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVR2|Q9NVR2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA processing|
|snRNA metabolic process|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.3|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.04|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.86|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.79|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.77|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.86|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.88|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.97|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.03|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.05|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.13|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.21|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.22|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.32|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.46|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.47|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.48|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.52|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.62|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.75|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.05|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.07|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.12|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.24|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.51|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:asun|ASUN]]|0.843|
|[[:human genes:c:c7orf26|C7orf26]]|0.798|
|[[:human genes:v:vwa9|VWA9]]|0.661|
|[[:human genes:u:urm1|URM1]]|0.436|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.428|
|[[:human genes:m:mocs3|MOCS3]]|0.426|
|[[:human genes:m:mlst8|MLST8]]|0.419|
|[[:human genes:c:ctu1|CTU1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 40/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|2/26|
|breast|6/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1755
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS10 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>