INTS1 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS1
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26173|26173]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N201|Q8N201]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611345|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3677|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2 snRNA 3-end processing|
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|RNA 3-end processing|
|nuclear membrane|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.21|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.94|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.74|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.81|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.93|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.06|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.09|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.16|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints6|INTS6]]|0.572|
|[[:human genes:i:ints8|INTS8]]|0.501|
|[[:human genes:c:chmp4b|CHMP4B]]|0.449|
|[[:human genes:c:cep192|CEP192]]|0.441|
|[[:human genes:c:copz1|COPZ1]]|0.423|
|[[:human genes:r:rrm1|RRM1]]|0.42|
|[[:human genes:n:nup160|NUP160]]|0.419|
|[[:human genes:c:cdc73|CDC73]]|0.419|
|[[:human genes:v:vps54|VPS54]]|0.417|
|[[:human genes:i:ints5|INTS5]]|0.416|
|[[:human genes:a:aamp|AAMP]]|0.415|
|[[:human genes:p:psma6|PSMA6]]|0.414|
|[[:human genes:p:psmb4|PSMB4]]|0.413|
|[[:human genes:i:ik|IK]]|0.413|
|[[:human genes:r:rpl9|RPL9]]|0.406|
|[[:human genes:r:rpl27|RPL27]]|0.403|
|[[:human genes:a:akirin2|AKIRIN2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 595/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|22/28|
|bone|23/26|
|breast|27/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|13/21|
|liver|18/20|
|lung|54/75|
|lymphocyte|10/16|
|ovary|24/26|
|pancreas|17/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|22/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 850
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS1 Expression in NALM6 Cells: 8.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>