INTS2 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS2
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57508|57508]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0H0|Q9H0H0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611346|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|intracellular|
|ncRNA transcription|
|RNA 3-end processing|
|nuclear membrane|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.26|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.16|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.11|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.01|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.94|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.93|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.92|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.84|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.83|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.83|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.82|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.82|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.76|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.75|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.72|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.85|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.04|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints6|INTS6]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1996
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS2 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>