INTS6 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS6
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26512|26512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL03|Q9UL03]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604331|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). {ECO:0000269|PubMed:15254679, ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|RNA 3-end processing|
|transmembrane signaling receptor activity|
|actin cytoskeleton|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.34|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.18|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.89|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.78|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.72|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.71|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.74|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.8|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.82|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.82|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.86|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.88|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.9|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.92|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.93|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.94|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.97|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.99|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.02|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.04|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.04|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.12|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.29|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.34|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.51|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|3.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints1|INTS1]]|0.572|
|[[:human genes:i:ints8|INTS8]]|0.556|
|[[:human genes:i:ints5|INTS5]]|0.534|
|[[:human genes:p:polr2j3|POLR2J3]]|0.527|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.485|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.482|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.47|
|[[:human genes:s:sf3a3|SF3A3]]|0.469|
|[[:human genes:c:cdc73|CDC73]]|0.465|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.464|
|[[:human genes:s:slc4a1|SLC4A1]]|0.45|
|[[:human genes:d:dnm2|DNM2]]|0.449|
|[[:human genes:n:nup160|NUP160]]|0.448|
|[[:human genes:i:ilf2|ILF2]]|0.448|
|[[:human genes:t:tceb3c|TCEB3C]]|0.447|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.444|
|[[:human genes:c:copz1|COPZ1]]|0.442|
|[[:human genes:p:prim1|PRIM1]]|0.441|
|[[:human genes:n:narfl|NARFL]]|0.44|
|[[:human genes:c:c14orf93|C14orf93]]|0.44|
|[[:human genes:a:akirin2|AKIRIN2]]|0.438|
|[[:human genes:s:sf3a2|SF3A2]]|0.437|
|[[:human genes:r:rbm39|RBM39]]|0.437|
|[[:human genes:t:ticrr|TICRR]]|0.433|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.433|
|[[:human genes:n:nbpf10|NBPF10]]|0.432|
|[[:human genes:s:snrnp70|SNRNP70]]|0.431|
|[[:human genes:c:cdc6|CDC6]]|0.429|
|[[:human genes:p:polr2a|POLR2A]]|0.428|
|[[:human genes:s:sf3a1|SF3A1]]|0.427|
|[[:human genes:p:psmb4|PSMB4]]|0.426|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.425|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.425|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.425|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.424|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.424|
|[[:human genes:r:rpl35|RPL35]]|0.423|
|[[:human genes:c:chmp4b|CHMP4B]]|0.423|
|[[:human genes:i:ints2|INTS2]]|0.423|
|[[:human genes:a:acsf2|ACSF2]]|0.422|
|[[:human genes:p:psma6|PSMA6]]|0.416|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.416|
|[[:human genes:r:rnf4|RNF4]]|0.414|
|[[:human genes:t:top1mt|TOP1MT]]|0.413|
|[[:human genes:r:rpl38|RPL38]]|0.413|
|[[:human genes:z:znf106|ZNF106]]|0.413|
|[[:human genes:s:snrpa1|SNRPA1]]|0.412|
|[[:human genes:v:vps54|VPS54]]|0.412|
|[[:human genes:p:pola2|POLA2]]|0.411|
|[[:human genes:p:prpf8|PRPF8]]|0.41|
|[[:human genes:c:ctr9|CTR9]]|0.409|
|[[:human genes:r:rsl1d1|RSL1D1]]|0.409|
|[[:human genes:e:eif3g|EIF3G]]|0.408|
|[[:human genes:i:iscu|ISCU]]|0.408|
|[[:human genes:o:orc1|ORC1]]|0.407|
|[[:human genes:r:rnf113a|RNF113A]]|0.407|
|[[:human genes:t:tspy8|TSPY8]]|0.406|
|[[:human genes:c:ccdc94|CCDC94]]|0.406|
|[[:human genes:p:pds5b|PDS5B]]|0.405|
|[[:human genes:a:ankle2|ANKLE2]]|0.404|
|[[:human genes:c:copg1|COPG1]]|0.404|
|[[:human genes:t:tfip11|TFIP11]]|0.403|
|[[:human genes:p:psmd1|PSMD1]]|0.403|
|[[:human genes:d:dido1|DIDO1]]|0.402|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:f:fam160a1|FAM160A1]]|0.401|
|[[:human genes:r:rpl14|RPL14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 311/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|4/28|
|bone|9/26|
|breast|14/33|
|central nervous system|23/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|6/21|
|liver|13/20|
|lung|36/75|
|lymphocyte|4/16|
|ovary|12/26|
|pancreas|9/24|
|peripheral nervous system|9/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|12/22|
|urinary tract|14/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 396
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS6 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>