INTS8 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS8
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55656|55656]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q75QN2|Q75QN2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|RNA 3-end processing|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.27|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.04|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.02|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.99|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.97|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.97|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.9|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.71|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.8|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.83|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.85|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|3.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints6|INTS6]]|0.556|
|[[:human genes:i:ints1|INTS1]]|0.501|
|[[:human genes:i:ints5|INTS5]]|0.45|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.447|
|[[:human genes:c:ctr9|CTR9]]|0.428|
|[[:human genes:i:ints7|INTS7]]|0.423|
|[[:human genes:p:pds5b|PDS5B]]|0.411|
|[[:human genes:e:esco1|ESCO1]]|0.41|
|[[:human genes:s:sf3a3|SF3A3]]|0.406|
|[[:human genes:b:brd2|BRD2]]|0.405|
|[[:human genes:i:ints12|INTS12]]|0.402|
|[[:human genes:w:wdr61|WDR61]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 85/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|1/28|
|bone|6/26|
|breast|5/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|1/21|
|liver|3/20|
|lung|4/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1816
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS8 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>