IPMK [The Human Chemical-Genetic Interaction Map Project]

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======= IPMK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPMK
  * **<color #00a2e8>Official Name</color>**: inositol polyphosphate multikinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=253430|253430]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFU5|Q8NFU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPMK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPMK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). {ECO:0000269|PubMed:12027805, ECO:0000269|PubMed:12223481}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IPK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity|
|inositol-1,4,5-trisphosphate 6-kinase activity|
|inositol tetrakisphosphate 5-kinase activity|
|inositol tetrakisphosphate 3-kinase activity|
|inositol tetrakisphosphate 6-kinase activity|
|flavonoid binding|
|inositol-1,4,5-trisphosphate 3-kinase activity|
|inositol trisphosphate metabolic process|
|necroptotic process|
|inositol phosphate biosynthetic process|
|programmed necrotic cell death|
|necrotic cell death|
|inositol phosphate metabolic process|
|polyol biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|phosphatidylinositol metabolic process|
|organic hydroxy compound biosynthetic process|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|small molecule biosynthetic process|
|nucleolus|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|programmed cell death|
|cell death|
|lipid metabolic process|
|phosphorylation|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.19|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.05|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.96|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.94|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.93|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.9|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.81|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.79|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.76|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.71|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.7|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.81|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.83|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.87|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.94|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.94|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.98|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.01|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.04|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.04|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.05|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.13|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.17|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.19|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.23|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.38|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.4|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.47|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.7|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.72|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.8|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.85|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.41|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|3.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:itpk1|ITPK1]]|0.7|
|[[:human genes:i:ippk|IPPK]]|0.692|
|[[:human genes:a:anp32a|ANP32A]]|0.463|
|[[:human genes:c:c7orf26|C7orf26]]|0.446|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11555
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPMK Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>