IPO9 [The Human Chemical-Genetic Interaction Map Project]

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======= IPO9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPO9
  * **<color #00a2e8>Official Name</color>**: importin 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55705|55705]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96P70|Q96P70]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPO9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPO9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620893|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear import signal receptor activity|
|Ran GTPase binding|
|protein import into nucleus|
|import into nucleus|
|histone binding|
|protein import|
|protein localization to nucleus|
|nuclear envelope|
|nucleocytoplasmic transport|
|nuclear transport|
|establishment of protein localization to organelle|
|protein localization to organelle|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.62|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.44|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.16|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.15|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.03|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.02|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.89|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.88|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.86|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.86|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.81|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.79|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.79|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.78|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.7|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.55|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:elmsan1|ELMSAN1]]|0.408|
|[[:human genes:r:rpp21|RPP21]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 367/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|13/28|
|bone|9/25|
|breast|20/33|
|central nervous system|23/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/15|
|kidney|14/21|
|liver|9/20|
|lung|41/75|
|lymphocyte|5/14|
|ovary|15/26|
|pancreas|19/24|
|peripheral nervous system|3/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|1/7|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|19/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2079
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPO9 Expression in NALM6 Cells: 7.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>