IQGAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= IQGAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IQGAP2
  * **<color #00a2e8>Official Name</color>**: IQ motif containing GTPase activating protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10788|10788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13576|Q13576]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IQGAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IQGAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605401|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|RasGAP C|
|RasGAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Arp2/3 complex binding|
|thrombin-activated receptor signaling pathway|
|GTPase inhibitor activity|
|Arp2/3 complex-mediated actin nucleation|
|Rho GTPase binding|
|actin nucleation|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|negative regulation of GTPase activity|
|Rac GTPase binding|
|microvillus|
|filopodium|
|positive regulation of actin filament polymerization|
|secretory granule membrane|
|positive regulation of protein polymerization|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|calmodulin binding|
|actin filament binding|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|actin binding|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|regulation of GTPase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|regulation of cytoskeleton organization|
|actin filament-based process|
|myeloid leukocyte activation|
|cell surface|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|leukocyte activation|
|regulation of cellular component biogenesis|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|secretion|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17752
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IQGAP2 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>