IQGAP3 [The Human Chemical-Genetic Interaction Map Project]

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======= IQGAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IQGAP3
  * **<color #00a2e8>Official Name</color>**: IQ motif containing GTPase activating protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=128239|128239]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VI3|Q86VI3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IQGAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IQGAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RasGAP C|
|RasGAP|
|CH|
|IQ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin VI light chain binding|
|positive regulation of mammary gland epithelial cell proliferation|
|regulation of mammary gland epithelial cell proliferation|
|ERK1 and ERK2 cascade|
|Rho GTPase binding|
|lateral plasma membrane|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|activation of MAPK activity|
|cell-cell junction|
|regulation of cell size|
|positive regulation of epithelial cell proliferation|
|calmodulin binding|
|Ras protein signal transduction|
|positive regulation of MAP kinase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|small GTPase mediated signal transduction|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|MAPK cascade|
|regulation of cellular component size|
|signal transduction by protein phosphorylation|
|regulation of GTPase activity|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.04|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.03|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.86|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.74|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.39|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12619
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IQGAP3 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>