ITGA2 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA2
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3673|3673]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17301|P17301]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192974|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin alpha2|
|VWA|
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of collagen binding|
|regulation of collagen binding|
|collagen receptor activity|
|integrin alpha2-beta1 complex|
|response to L-ascorbic acid|
|collagen binding involved in cell-matrix adhesion|
|positive regulation of alkaline phosphatase activity|
|positive regulation of transmission of nerve impulse|
|regulation of alkaline phosphatase activity|
|skin morphogenesis|
|hypotonic response|
|response to parathyroid hormone|
|positive regulation of membrane invagination|
|collagen-activated signaling pathway|
|positive regulation of phagocytosis, engulfment|
|hepatocyte differentiation|
|detection of mechanical stimulus involved in sensory perception of pain|
|basal part of cell|
|regulation of phagocytosis, engulfment|
|heparan sulfate proteoglycan binding|
|regulation of membrane invagination|
|regulation of transmission of nerve impulse|
|cell adhesion mediated by integrin|
|response to muscle activity|
|laminin binding|
|integrin complex|
|positive regulation of collagen biosynthetic process|
|positive regulation of positive chemotaxis|
|mesodermal cell differentiation|
|regulation of positive chemotaxis|
|positive regulation of collagen metabolic process|
|cell-substrate adherens junction assembly|
|substrate-dependent cell migration|
|focal adhesion assembly|
|detection of mechanical stimulus involved in sensory perception|
|positive regulation of smooth muscle contraction|
|positive regulation of phosphatase activity|
|regulation of collagen biosynthetic process|
|adherens junction assembly|
|cellular response to estradiol stimulus|
|positive regulation of smooth muscle cell migration|
|regulation of collagen metabolic process|
|cell-substrate junction assembly|
|detection of mechanical stimulus|
|positive regulation of muscle contraction|
|response to amine|
|axon terminus|
|positive regulation of DNA binding|
|positive regulation of dephosphorylation|
|regulation of smooth muscle cell migration|
|regulation of smooth muscle contraction|
|positive regulation of nervous system process|
|collagen binding|
|response to activity|
|mesoderm formation|
|positive regulation of phagocytosis|
|mesoderm morphogenesis|
|sensory perception of pain|
|virus receptor activity|
|response to osmotic stress|
|cellular response to mechanical stimulus|
|amyloid-beta binding|
|adherens junction organization|
|positive regulation of smooth muscle cell proliferation|
|response to vitamin|
|integrin-mediated signaling pathway|
|viral entry into host cell|
|regulation of phagocytosis|
|positive regulation of endocytosis|
|entry into host|
|entry into host cell|
|formation of primary germ layer|
|detection of external stimulus|
|detection of abiotic stimulus|
|mesoderm development|
|positive regulation of translation|
|regulation of DNA binding|
|liver development|
|cell-matrix adhesion|
|mammary gland development|
|positive regulation of leukocyte migration|
|hepaticobiliary system development|
|integrin binding|
|regulation of smooth muscle cell proliferation|
|positive regulation of chemotaxis|
|response to estradiol|
|regulation of nervous system process|
|positive regulation of inflammatory response|
|positive regulation of epithelial cell migration|
|response to monosaccharide|
|positive regulation of cellular amide metabolic process|
|interaction with host|
|gastrulation|
|regulation of muscle contraction|
|sensory perception of mechanical stimulus|
|cell junction assembly|
|response to carbohydrate|
|regulation of phosphatase activity|
|positive regulation of binding|
|female pregnancy|
|cell-substrate adhesion|
|regulation of leukocyte migration|
|viral life cycle|
|regulation of endocytosis|
|multi-multicellular organism process|
|regulation of dephosphorylation|
|response to mechanical stimulus|
|regulation of chemotaxis|
|cell junction organization|
|response to nutrient|
|regulation of epithelial cell migration|
|regulation of muscle system process|
|protein-containing complex binding|
|blood coagulation|
|coagulation|
|hemostasis|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|regulation of inflammatory response|
|extracellular matrix organization|
|response to hypoxia|
|response to acid chemical|
|regulation of translation|
|response to decreased oxygen levels|
|regulation of binding|
|response to oxygen levels|
|positive regulation of cell projection organization|
|skin development|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of cellular amide metabolic process|
|positive regulation of cell adhesion|
|gland development|
|focal adhesion|
|positive regulation of defense response|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to lipid|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|detection of stimulus involved in sensory perception|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|regulation of system process|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|cell surface|
|regulation of cell adhesion|
|epithelial cell differentiation|
|detection of stimulus|
|perinuclear region of cytoplasm|
|viral process|
|regulation of cell projection organization|
|regulation of defense response|
|positive regulation of hydrolase activity|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|sensory perception|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|locomotion|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15659
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA2 Expression in NALM6 Cells: 2.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>