ITGA3 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA3
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3675|3675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26006|P26006]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605025|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin alpha2|
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alpha3-beta1 complex|
|growth cone filopodium|
|invadopodium membrane|
|dendritic spine maintenance|
|renal filtration|
|filopodium membrane|
|negative regulation of Rho protein signal transduction|
|laminin binding|
|integrin complex|
|mesodermal cell differentiation|
|exploration behavior|
|synaptic membrane|
|fibronectin binding|
|response to gonadotropin|
|excitatory synapse|
|dendritic spine organization|
|cell periphery|
|neuron projection organization|
|cellular component maintenance|
|negative regulation of Ras protein signal transduction|
|positive regulation of protein localization to plasma membrane|
|negative regulation of small GTPase mediated signal transduction|
|positive regulation of protein localization to cell periphery|
|maternal process involved in female pregnancy|
|collagen binding|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of BMP signaling pathway|
|postsynapse organization|
|integrin-mediated signaling pathway|
|regulation of protein localization to plasma membrane|
|protease binding|
|renal system process|
|formation of primary germ layer|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of protein localization to cell periphery|
|regulation of cellular response to transforming growth factor beta stimulus|
|memory|
|neuron migration|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein localization to membrane|
|nephron development|
|mesoderm development|
|cell-matrix adhesion|
|integrin binding|
|positive regulation of epithelial cell migration|
|regulation of Rho protein signal transduction|
|gastrulation|
|lung development|
|respiratory tube development|
|female pregnancy|
|negative regulation of cell projection organization|
|cell-substrate adhesion|
|regulation of protein localization to membrane|
|respiratory system development|
|basolateral plasma membrane|
|receptor complex|
|multi-multicellular organism process|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of Ras protein signal transduction|
|protein domain specific binding|
|learning or memory|
|kidney development|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|renal system development|
|cognition|
|urogenital system development|
|positive regulation of cellular protein localization|
|extracellular matrix organization|
|regulation of small GTPase mediated signal transduction|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|leukocyte migration|
|positive regulation of cell projection organization|
|skin development|
|extracellular structure organization|
|external side of plasma membrane|
|positive regulation of cell adhesion|
|focal adhesion|
|positive regulation of neurogenesis|
|protein heterodimerization activity|
|regulation of neuron projection development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|cell surface|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to drug|
|regulation of protein localization|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.14|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.06|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.85|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.81|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.71|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.74|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5407
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA3 Expression in NALM6 Cells: 3.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>