ITGAM [The Human Chemical-Genetic Interaction Map Project]

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======= ITGAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGAM
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3684|3684]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11215|P11215]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). {ECO:0000250|UniProtKB:P05555, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:28807980, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FG-GAP|
|Integrin alpha2|
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alphaM-beta2 complex|
|positive regulation of hippocampal neuron apoptotic process|
|positive regulation of prostaglandin-E synthase activity|
|regulation of prostaglandin-E synthase activity|
|positive regulation of microglial cell mediated cytotoxicity|
|regulation of microglial cell mediated cytotoxicity|
|vertebrate eye-specific patterning|
|negative regulation of dopamine metabolic process|
|complement-mediated synapse pruning|
|regulation of hippocampal neuron apoptotic process|
|positive regulation of neutrophil degranulation|
|positive regulation of neutrophil activation|
|negative regulation of catecholamine metabolic process|
|complement component C3b binding|
|ectodermal cell differentiation|
|negative regulation of cellular amine metabolic process|
|regulation of neutrophil degranulation|
|regulation of isomerase activity|
|positive regulation of isomerase activity|
|synapse pruning|
|regulation of neutrophil activation|
|cargo receptor activity|
|positive regulation of superoxide anion generation|
|toll-like receptor 4 signaling pathway|
|regulation of catecholamine metabolic process|
|ectoderm development|
|regulation of dopamine metabolic process|
|regulation of superoxide anion generation|
|amyloid-beta clearance|
|positive regulation of leukocyte degranulation|
|integrin complex|
|microglial cell activation|
|plasma membrane raft|
|leukocyte activation involved in inflammatory response|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of protein targeting to membrane|
|regulation of superoxide metabolic process|
|regulation of protein targeting to membrane|
|glial cell activation|
|neuroinflammatory response|
|regulation of leukocyte degranulation|
|macrophage activation|
|positive regulation of regulated secretory pathway|
|positive regulation of neuron apoptotic process|
|positive regulation of leukocyte mediated cytotoxicity|
|heat shock protein binding|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of cell killing|
|tertiary granule membrane|
|regulation of leukocyte mediated cytotoxicity|
|regulation of cellular amine metabolic process|
|amyloid-beta binding|
|regulation of protein targeting|
|positive regulation of exocytosis|
|positive regulation of neuron death|
|specific granule membrane|
|integrin-mediated signaling pathway|
|positive regulation of reactive oxygen species metabolic process|
|toll-like receptor signaling pathway|
|regulation of cell killing|
|positive regulation of protein localization to membrane|
|pattern recognition receptor signaling pathway|
|phagocytosis, engulfment|
|positive regulation of leukocyte mediated immunity|
|plasma membrane invagination|
|membrane invagination|
|positive regulation of intracellular protein transport|
|regulation of regulated secretory pathway|
|regulation of reactive oxygen species metabolic process|
|regulation of protein localization to membrane|
|regulation of leukocyte mediated immunity|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|positive regulation of immune effector process|
|regulation of exocytosis|
|regulation of intracellular protein transport|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|activation of innate immune response|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse organization|
|apoptotic signaling pathway|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|phagocytosis|
|regionalization|
|extracellular matrix organization|
|positive regulation of innate immune response|
|regulation of intracellular transport|
|visual system development|
|positive regulation of response to biotic stimulus|
|sensory system development|
|leukocyte migration|
|forebrain development|
|extracellular structure organization|
|external side of plasma membrane|
|cellular component disassembly|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of secretion|
|pattern specification process|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of immune effector process|
|positive regulation of defense response|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|endocytosis|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|import into cell|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|head development|
|exocytosis|
|regulation of secretion|
|membrane organization|
|positive regulation of immune response|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|central nervous system development|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cell activation|
|localization of cell|
|cell motility|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|extracellular space|
|regulation of immune system process|
|regulation of cell death|
|tissue development|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.479|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGAM Expression in NALM6 Cells: -0.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>