ITGB6 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGB6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB6
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3694|3694]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18564|P18564]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). {ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:17545607}. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269|PubMed:24367260}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin beta|
|Integrin b cyt|
|Integrin B tail|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transforming growth factor-beta secretion|
|integrin alphav-beta6 complex|
|regulation of transforming growth factor beta activation|
|cell adhesion mediated by integrin|
|integrin complex|
|regulation of transforming growth factor beta production|
|cytokine secretion|
|virus receptor activity|
|integrin-mediated signaling pathway|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|cell-matrix adhesion|
|integrin binding|
|cytokine production|
|interaction with host|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|cell-substrate adhesion|
|viral life cycle|
|signaling receptor activity|
|receptor complex|
|extracellular matrix organization|
|extracellular structure organization|
|external side of plasma membrane|
|focal adhesion|
|centrosome|
|inflammatory response|
|cell junction|
|cell surface|
|regulation of cytokine production|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cell adhesion|
|biological adhesion|
|cell migration|
|secretion by cell|
|export from cell|
|cell motility|
|localization of cell|
|secretion|
|locomotion|
|defense response|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.83|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.73|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.7|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.8|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18852
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB6 Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>