ITGB7 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGB7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB7
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3695|3695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26010|P26010]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147559|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin b cyt|
|Integrin beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alpha4-beta7 complex|
|cell-matrix adhesion involved in ameboidal cell migration|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|cell adhesion mediated by integrin|
|integrin complex|
|T cell migration|
|heterotypic cell-cell adhesion|
|cellular extravasation|
|receptor clustering|
|leukocyte cell-cell adhesion|
|substrate adhesion-dependent cell spreading|
|cell adhesion molecule binding|
|lymphocyte migration|
|virus receptor activity|
|localization within membrane|
|integrin-mediated signaling pathway|
|viral entry into host cell|
|entry into host|
|entry into host cell|
|cell-matrix adhesion|
|integrin binding|
|interaction with host|
|ameboidal-type cell migration|
|cell-substrate adhesion|
|viral life cycle|
|signaling receptor activity|
|receptor complex|
|extracellular matrix organization|
|leukocyte migration|
|extracellular structure organization|
|focal adhesion|
|protein localization to membrane|
|cell-cell adhesion|
|cell morphogenesis involved in differentiation|
|cell surface|
|viral process|
|cell morphogenesis|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|cell migration|
|localization of cell|
|cell motility|
|regulation of immune response|
|locomotion|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|regulation of immune system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.11|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB7 Expression in NALM6 Cells: 1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>