ITIH2 [The Human Chemical-Genetic Interaction Map Project]

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======= ITIH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITIH2
  * **<color #00a2e8>Official Name</color>**: inter-alpha-trypsin inhibitor heavy chain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3698|3698]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19823|P19823]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITIH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITIH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWA|
|VIT|
|ITI HC C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hyaluronan metabolic process|
|endopeptidase inhibitor activity|
|serine-type endopeptidase inhibitor activity|
|mucopolysaccharide metabolic process|
|blood microparticle|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|endoplasmic reticulum lumen|
|negative regulation of proteolysis|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|small molecule metabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp302|35°C R06 exp302]]|-1.88|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.75|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.71|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.09|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.09|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.11|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITIH2 Expression in NALM6 Cells: -1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>