IZUMO1R [The Human Chemical-Genetic Interaction Map Project]

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======= IZUMO1R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IZUMO1R
  * **<color #00a2e8>Official Name</color>**: IZUMO1 receptor, JUNO
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=390243|390243]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6ND01|A6ND01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IZUMO1R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IZUMO1R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615737|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. {ECO:0000250|UniProtKB:Q9EQF4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folate rec|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|folic acid binding|
|fusion of sperm to egg plasma membrane involved in single fertilization|
|anchored component of external side of plasma membrane|
|plasma membrane fusion|
|sperm-egg recognition|
|cell-cell recognition|
|membrane fusion|
|single fertilization|
|fertilization|
|signaling receptor activity|
|cell recognition|
|signaling receptor binding|
|cellular process involved in reproduction in multicellular organism|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|cell adhesion|
|biological adhesion|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.7|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.81|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.656|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IZUMO1R Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>