JAG2 [The Human Chemical-Genetic Interaction Map Project]

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======= JAG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JAG2
  * **<color #00a2e8>Official Name</color>**: jagged canonical Notch ligand 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3714|3714]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y219|Q9Y219]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JAG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JAG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSL|
|EGF|
|MNNL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial cell apoptotic process involved in palatal shelf morphogenesis|
|gamma-delta T cell differentiation|
|inner ear receptor cell fate commitment|
|auditory receptor cell fate commitment|
|gamma-delta T cell activation|
|respiratory system process|
|epithelial cell fate commitment|
|apoptotic process involved in morphogenesis|
|thymic T cell selection|
|secondary palate development|
|inner ear auditory receptor cell differentiation|
|Notch binding|
|apoptotic process involved in development|
|epithelial cell apoptotic process|
|hair cell differentiation|
|T cell selection|
|respiratory gaseous exchange by respiratory system|
|negative regulation of Notch signaling pathway|
|neuroepithelial cell differentiation|
|T cell differentiation in thymus|
|inner ear receptor cell differentiation|
|positive regulation of Notch signaling pathway|
|mechanoreceptor differentiation|
|neuron fate commitment|
|odontogenesis of dentin-containing tooth|
|roof of mouth development|
|columnar/cuboidal epithelial cell differentiation|
|regulation of Notch signaling pathway|
|odontogenesis|
|Notch signaling pathway|
|T cell differentiation|
|morphogenesis of embryonic epithelium|
|growth factor activity|
|inner ear development|
|ear development|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|epidermal cell differentiation|
|leukocyte differentiation|
|in utero embryonic development|
|lymphocyte activation|
|epidermis development|
|morphogenesis of an epithelium|
|skeletal system development|
|spermatogenesis|
|sensory organ development|
|hemopoiesis|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|regulation of cell adhesion|
|epithelial cell differentiation|
|gamete generation|
|calcium ion binding|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|apoptotic process|
|leukocyte activation|
|animal organ morphogenesis|
|embryo development|
|multi-organism reproductive process|
|neuron differentiation|
|programmed cell death|
|cell activation|
|cell death|
|epithelium development|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|generation of neurons|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.9|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JAG2 Expression in NALM6 Cells: -0.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>