KANK1 [The Human Chemical-Genetic Interaction Map Project]

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======= KANK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KANK1
  * **<color #00a2e8>Official Name</color>**: KN motif and ankyrin repeat domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23189|23189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14678|Q14678]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KANK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KANK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607704|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KN motif|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lamellipodium morphogenesis|
|glomerular visceral epithelial cell migration|
|negative regulation of lamellipodium organization|
|negative regulation of ruffle assembly|
|regulation of lamellipodium morphogenesis|
|negative regulation of substrate adhesion-dependent cell spreading|
|regulation of establishment of cell polarity|
|negative regulation of Rho protein signal transduction|
|regulation of establishment or maintenance of cell polarity|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of ruffle assembly|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|regulation of lamellipodium organization|
|negative regulation of Ras protein signal transduction|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of actin filament polymerization|
|positive regulation of wound healing|
|negative regulation of small GTPase mediated signal transduction|
|negative regulation of cell-substrate adhesion|
|positive regulation of response to wounding|
|regulation of insulin receptor signaling pathway|
|negative regulation of protein polymerization|
|regulation of cellular response to insulin stimulus|
|beta-catenin binding|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|ruffle membrane|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|regulation of wound healing|
|negative regulation of cytoskeleton organization|
|regulation of Rho protein signal transduction|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of neuron projection development|
|regulation of actin filament polymerization|
|regulation of response to wounding|
|ameboidal-type cell migration|
|positive regulation of Wnt signaling pathway|
|negative regulation of cell projection organization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of cell-substrate adhesion|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|regulation of Ras protein signal transduction|
|negative regulation of cell migration|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|regulation of canonical Wnt signaling pathway|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|cell population proliferation|
|actin filament-based process|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.72|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.83|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.84|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KANK1 Expression in NALM6 Cells: 3.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>