KANSL1 [The Human Chemical-Genetic Interaction Map Project]

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======= KANSL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KANSL1
  * **<color #00a2e8>Official Name</color>**: KAT8 regulatory NSL complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284058|284058]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3B3|Q7Z3B3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KANSL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KANSL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612452|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NSL complex|
|histone acetyltransferase activity (H4-K16 specific)|
|histone acetyltransferase activity (H4-K8 specific)|
|histone acetyltransferase activity (H4-K5 specific)|
|histone H4-K8 acetylation|
|histone H4-K5 acetylation|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|histone acetyltransferase binding|
|MLL1 complex|
|histone H4 acetylation|
|condensed chromosome kinetochore|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.99|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.75|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.72|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.75|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.78|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.8|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.87|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.88|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.91|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.01|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.07|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.09|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.09|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.12|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.13|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.36|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.41|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.46|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcrs1|MCRS1]]|0.519|
|[[:human genes:k:kansl3|KANSL3]]|0.493|
|[[:human genes:k:kansl2|KANSL2]]|0.466|
|[[:human genes:p:prim1|PRIM1]]|0.44|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 31/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/25|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1373
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KANSL1 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>