KANSL2 [The Human Chemical-Genetic Interaction Map Project]

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======= KANSL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KANSL2
  * **<color #00a2e8>Official Name</color>**: KAT8 regulatory NSL complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54934|54934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9L4|Q9H9L4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KANSL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KANSL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615488|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NSL complex|
|histone acetyltransferase activity (H4-K8 specific)|
|histone acetyltransferase activity (H4-K5 specific)|
|histone acetyltransferase activity (H4-K16 specific)|
|histone H4-K5 acetylation|
|histone H4-K8 acetylation|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|actin cytoskeleton|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.08|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.06|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.94|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.9|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.89|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.79|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.76|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.87|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.92|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.93|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.96|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.99|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.05|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kansl1|KANSL1]]|0.466|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.457|
|[[:human genes:m:mcrs1|MCRS1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 77/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|6/28|
|bone|5/25|
|breast|2/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|5/21|
|liver|2/20|
|lung|8/75|
|lymphocyte|3/14|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 889
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KANSL2 Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>