KAT5 [The Human Chemical-Genetic Interaction Map Project]

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======= KAT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KAT5
  * **<color #00a2e8>Official Name</color>**: lysine acetyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10524|10524]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92993|Q92993]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KAT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KAT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601409|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MOZ SAS|
|Tudor-knot|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Piccolo NuA4 histone acetyltransferase complex|
|peptide-lysine-N-acetyltransferase activity|
|H4 histone acetyltransferase activity|
|Swr1 complex|
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|DNA damage response, signal transduction resulting in transcription|
|acetyltransferase activity|
|NuA4 histone acetyltransferase complex|
|DNA double-strand break processing|
|negative regulation of interleukin-2 production|
|histone acetyltransferase complex|
|beta-catenin-TCF complex assembly|
|androgen receptor signaling pathway|
|cellular response to estradiol stimulus|
|repressing transcription factor binding|
|positive regulation of protein acetylation|
|androgen receptor binding|
|histone acetyltransferase activity|
|regulation of interleukin-2 production|
|histone H4 acetylation|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|intracellular steroid hormone receptor signaling pathway|
|regulation of protein acetylation|
|DNA damage response, signal transduction by p53 class mediator|
|signal transduction in response to DNA damage|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|steroid hormone mediated signaling pathway|
|positive regulation of autophagy|
|signal transduction by p53 class mediator|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|response to estradiol|
|protein acetylation|
|response to ionizing radiation|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of signal transduction by p53 class mediator|
|double-strand break repair|
|cellular response to steroid hormone stimulus|
|protein acylation|
|transcription factor complex|
|DNA replication|
|nuclear chromatin|
|negative regulation of cytokine production|
|transcription coactivator activity|
|peptidyl-lysine modification|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|response to steroid hormone|
|regulation of autophagy|
|proteasomal protein catabolic process|
|positive regulation of cellular catabolic process|
|histone modification|
|covalent chromatin modification|
|positive regulation of catabolic process|
|response to radiation|
|DNA repair|
|cellular response to lipid|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|regulation of growth|
|protein catabolic process|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|chromatin organization|
|viral process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|response to lipid|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|regulation of catabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prr12|PRR12]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 78/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|2/25|
|breast|4/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|4/21|
|liver|2/20|
|lung|8/75|
|lymphocyte|3/14|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 271
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KAT5 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>