KAT8 [The Human Chemical-Genetic Interaction Map Project]

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======= KAT8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KAT8
  * **<color #00a2e8>Official Name</color>**: lysine acetyltransferase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84148|84148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7Z6|Q9H7Z6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KAT8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KAT8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tudor-knot|
|MOZ SAS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MSL complex|
|histone acetyltransferase activity (H4-K5 specific)|
|histone acetyltransferase activity (H4-K16 specific)|
|histone acetyltransferase activity (H4-K8 specific)|
|histone H4-K8 acetylation|
|histone H4-K5 acetylation|
|acetyltransferase activity|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|MLL1 complex|
|histone acetyltransferase activity|
|histone H4 acetylation|
|methylated histone binding|
|kinetochore|
|nuclear matrix|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|protein acetylation|
|protein acylation|
|myeloid cell differentiation|
|nuclear chromatin|
|peptidyl-lysine modification|
|regulation of autophagy|
|transcription factor binding|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|chromatin organization|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|regulation of catabolic process|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.86|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.82|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.72|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.71|
|[[:results:exp302|35°C R06 exp302]]|1.89|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.97|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.03|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.32|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 381/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|12/28|
|bone|10/25|
|breast|19/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|9/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/15|
|kidney|10/21|
|liver|10/20|
|lung|44/75|
|lymphocyte|6/14|
|ovary|18/26|
|pancreas|12/24|
|peripheral nervous system|12/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|5/7|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KAT8 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>