KCNAB2 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNAB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNAB2
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily A regulatory beta subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8514|8514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13303|Q13303]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNAB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNAB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601142|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pinceau fiber|
|NADPH oxidation|
|juxtaparanode region of axon|
|aldo-keto reductase (NADP) activity|
|NADP metabolic process|
|regulation of protein localization to cell surface|
|potassium channel regulator activity|
|axon terminus|
|voltage-gated potassium channel activity|
|extrinsic component of cytoplasmic side of plasma membrane|
|tertiary granule membrane|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|hematopoietic progenitor cell differentiation|
|specific granule membrane|
|regulation of potassium ion transport|
|neuromuscular process|
|potassium ion transmembrane transport|
|potassium ion transport|
|postsynaptic density|
|microtubule|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|cell junction|
|hemopoiesis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|inorganic ion transmembrane transport|
|immune system development|
|regulation of ion transport|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cation transport|
|regulation of cellular localization|
|leukocyte activation|
|ion transmembrane transport|
|oxidation-reduction process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|transmembrane transport|
|ion transport|
|nervous system process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15727
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNAB2 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>