KCNJ11 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNJ11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNJ11
  * **<color #00a2e8>Official Name</color>**: potassium inwardly rectifying channel subfamily J member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3767|3767]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14654|Q14654]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNJ11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNJ11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600937|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. {ECO:0000250, ECO:0000269|PubMed:17855752, ECO:0000269|PubMed:28842488, ECO:0000269|PubMed:9831708}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inward rectifying potassium channel|
|ATP-activated inward rectifier potassium channel activity|
|cell body fiber|
|cellular response to nicotine|
|potassium ion binding|
|axolemma|
|ankyrin binding|
|inward rectifier potassium channel activity|
|myelin sheath|
|response to ATP|
|negative regulation of insulin secretion|
|response to testosterone|
|potassium ion import across plasma membrane|
|T-tubule|
|intercalated disc|
|negative regulation of peptide hormone secretion|
|response to nicotine|
|response to ischemia|
|positive regulation of protein localization to plasma membrane|
|heat shock protein binding|
|voltage-gated potassium channel activity|
|positive regulation of protein localization to cell periphery|
|negative regulation of hormone secretion|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|cellular response to carbohydrate stimulus|
|acrosomal vesicle|
|cellular glucose homeostasis|
|regulation of protein localization to plasma membrane|
|import across plasma membrane|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|glucose metabolic process|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|ion channel binding|
|negative regulation of protein secretion|
|response to estradiol|
|response to organophosphorus|
|response to glucose|
|negative regulation of peptide secretion|
|positive regulation of cation transmembrane transport|
|response to hexose|
|response to monosaccharide|
|response to purine-containing compound|
|positive regulation of ion transmembrane transport|
|hexose metabolic process|
|potassium ion transmembrane transport|
|potassium ion transport|
|response to carbohydrate|
|regulation of cation channel activity|
|regulation of insulin secretion|
|nuclear envelope|
|negative regulation of protein transport|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|protein C-terminus binding|
|response to ketone|
|monosaccharide metabolic process|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|cellular response to toxic substance|
|response to nutrient|
|negative regulation of secretion|
|cellular response to tumor necrosis factor|
|regulation of heart contraction|
|regulation of ion transmembrane transporter activity|
|response to tumor necrosis factor|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|endosome|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|neuronal cell body|
|monovalent inorganic cation transport|
|cellular response to drug|
|regulation of membrane potential|
|regulation of protein secretion|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of peptide secretion|
|response to nutrient levels|
|response to toxic substance|
|response to extracellular stimulus|
|regulation of hormone levels|
|regulation of cellular protein localization|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|positive regulation of transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|chemical homeostasis|
|mitochondrion|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8975
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNJ11 Expression in NALM6 Cells: 2.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>