KCNK2 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNK2
  * **<color #00a2e8>Official Name</color>**: potassium two pore domain channel subfamily K member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3776|3776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95069|O95069]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603219|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cellular response to hypoxia|
|astrocyte projection|
|outward rectifier potassium channel activity|
|regulation of cellular response to hypoxia|
|negative regulation of cardiac muscle cell proliferation|
|potassium ion leak channel activity|
|stabilization of membrane potential|
|negative regulation of heart growth|
|negative regulation of cardiac muscle tissue growth|
|calyx of Held|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|negative regulation of DNA biosynthetic process|
|regulation of cardiac muscle cell proliferation|
|negative regulation of striated muscle tissue development|
|response to axon injury|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|cochlea development|
|regulation of cardiac muscle tissue growth|
|regulation of heart growth|
|regulation of cardiac muscle tissue development|
|voltage-gated potassium channel complex|
|regulation of organ growth|
|negative regulation of developmental growth|
|regulation of DNA biosynthetic process|
|memory|
|negative regulation of DNA metabolic process|
|cardiac ventricle development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|potassium ion transmembrane transport|
|potassium ion transport|
|cardiac chamber development|
|cellular response to hypoxia|
|inner ear development|
|cellular response to decreased oxygen levels|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|ear development|
|negative regulation of growth|
|learning or memory|
|cognition|
|apical plasma membrane|
|regulation of developmental growth|
|response to hypoxia|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|neuronal cell body|
|response to oxygen levels|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|heart development|
|sensory organ development|
|inorganic cation transmembrane transport|
|response to wounding|
|behavior|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of growth|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of cellular response to stress|
|cation transport|
|circulatory system development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|ion transmembrane transport|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|regulation of cell death|
|cellular response to stress|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.54|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15902
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNK2 Expression in NALM6 Cells: 0.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>