KDM2A [The Human Chemical-Genetic Interaction Map Project]

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======= KDM2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDM2A
  * **<color #00a2e8>Official Name</color>**: lysine demethylase 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22992|22992]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2K7|Q9Y2K7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDM2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDM2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605657|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
|F-box|
|zf-CXXC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone demethylase activity (H3-K36 specific)|
|histone H3-K36 demethylation|
|negative regulation of transcription by competitive promoter binding|
|histone lysine demethylation|
|histone demethylation|
|protein demethylation|
|protein dealkylation|
|double-strand break repair via nonhomologous end joining|
|circadian regulation of gene expression|
|demethylation|
|non-recombinational repair|
|regulation of circadian rhythm|
|circadian rhythm|
|double-strand break repair|
|rhythmic process|
|histone modification|
|covalent chromatin modification|
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|oxidation-reduction process|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular response to stress|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.82|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 127/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|7/28|
|bone|4/25|
|breast|7/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|5/21|
|liver|3/20|
|lung|10/75|
|lymphocyte|3/14|
|ovary|7/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 998
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDM2A Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>