KIAA0020 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA0020 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PUM3
  * **<color #00a2e8>Official Name</color>**: pumilio RNA binding family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9933|9933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15397|Q15397]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA0020&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA0020|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). {ECO:0000250|UniProtKB:X1WGX5, ECO:0000269|PubMed:21266351, ECO:0000269|PubMed:25512524}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CPL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein ADP-ribosylation|
|chromosome|
|nucleolus|
|endoplasmic reticulum|
|RNA binding|
|DNA binding|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.31|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.27|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.19|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.93|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.83|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.76|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.71|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.01|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.49|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrto4|MRTO4]]|0.468|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA0020 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>