KIAA0947 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA0947 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ICE1
  * **<color #00a2e8>Official Name</color>**: interactor of little elongation complex ELL subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23379|23379]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2F5|Q9Y2F5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA0947&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA0947|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone locus body|
|snRNA transcription by RNA polymerase III|
|positive regulation of transcription by RNA polymerase III|
|regulation of transcription by RNA polymerase III|
|transcriptionally active chromatin|
|transcription elongation factor complex|
|transcription by RNA polymerase III|
|Cajal body|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|positive regulation of protein complex assembly|
|nuclear body|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|transcription by RNA polymerase II|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein homodimerization activity|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|regulation of protein localization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.73|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.76|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.77|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.83|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.85|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.9|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.91|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.06|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.26|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.31|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.518|
|[[:human genes:c:chd4|CHD4]]|0.498|
|[[:human genes:s:sf3a3|SF3A3]]|0.489|
|[[:human genes:p:psmb4|PSMB4]]|0.482|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.477|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.474|
|[[:human genes:t:tceb3c|TCEB3C]]|0.473|
|[[:human genes:v:vasn|VASN]]|0.464|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.459|
|[[:human genes:p:psmd2|PSMD2]]|0.453|
|[[:human genes:i:ints5|INTS5]]|0.449|
|[[:human genes:n:nol10|NOL10]]|0.449|
|[[:human genes:w:wdr75|WDR75]]|0.448|
|[[:human genes:r:rpl6|RPL6]]|0.448|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:b:brd2|BRD2]]|0.444|
|[[:human genes:t:ticrr|TICRR]]|0.444|
|[[:human genes:t:twistnb|TWISTNB]]|0.439|
|[[:human genes:p:psma7|PSMA7]]|0.436|
|[[:human genes:r:rps9|RPS9]]|0.434|
|[[:human genes:p:prim1|PRIM1]]|0.434|
|[[:human genes:c:c14orf93|C14orf93]]|0.431|
|[[:human genes:c:cgb2|CGB2]]|0.431|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.429|
|[[:human genes:c:cope|COPE]]|0.429|
|[[:human genes:e:exosc9|EXOSC9]]|0.428|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.428|
|[[:human genes:s:sf3b2|SF3B2]]|0.425|
|[[:human genes:c:ctage4|CTAGE4]]|0.424|
|[[:human genes:p:psma6|PSMA6]]|0.422|
|[[:human genes:r:rps2|RPS2]]|0.419|
|[[:human genes:r:rps5|RPS5]]|0.417|
|[[:human genes:p:pole|POLE]]|0.416|
|[[:human genes:r:rpl15|RPL15]]|0.415|
|[[:human genes:c:cacna1a|CACNA1A]]|0.413|
|[[:human genes:n:nup160|NUP160]]|0.411|
|[[:human genes:r:rps3a|RPS3A]]|0.411|
|[[:human genes:a:akirin2|AKIRIN2]]|0.411|
|[[:human genes:o:orc1|ORC1]]|0.409|
|[[:human genes:p:psmb2|PSMB2]]|0.409|
|[[:human genes:r:rps16|RPS16]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:r:rpl30|RPL30]]|0.408|
|[[:human genes:p:pola1|POLA1]]|0.405|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.404|
|[[:human genes:r:rnf113a|RNF113A]]|0.403|
|[[:human genes:n:nelfcd|NELFCD]]|0.403|
|[[:human genes:r:rps10|RPS10]]|0.403|
|[[:human genes:s:slc6a17|SLC6A17]]|0.403|
|[[:human genes:n:npipb5|NPIPB5]]|0.401|
|[[:human genes:t:tspy2|TSPY2]]|0.4|
|[[:human genes:m:mfsd12|MFSD12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 110/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|3/28|
|bone|5/26|
|breast|8/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|5/21|
|liver|4/20|
|lung|10/75|
|lymphocyte|5/16|
|ovary|8/26|
|pancreas|2/24|
|peripheral nervous system|3/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1600
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA0947 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>