KIAA1161 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA1161 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYORG
  * **<color #00a2e8>Official Name</color>**: myogenesis regulating glycosidase (putative)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57462|57462]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NSJ0|Q6NSJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1161&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1161|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618255|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2. {ECO:0000250|UniProtKB:Q69ZQ1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 31|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hydrolase activity, hydrolyzing O-glycosyl compounds|
|positive regulation of insulin-like growth factor receptor signaling pathway|
|regulation of insulin-like growth factor receptor signaling pathway|
|skeletal muscle fiber development|
|myotube cell development|
|myotube differentiation|
|muscle fiber development|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|muscle cell development|
|positive regulation of protein kinase B signaling|
|striated muscle cell differentiation|
|regulation of protein kinase B signaling|
|nuclear membrane|
|muscle cell differentiation|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|carbohydrate metabolic process|
|muscle structure development|
|endoplasmic reticulum membrane|
|positive regulation of intracellular signal transduction|
|cell development|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1161 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>