KIAA1429 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA1429 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VIRMA
  * **<color #00a2e8>Official Name</color>**: vir like m6A methyltransferase associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25962|25962]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q69YN4|Q69YN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1429&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1429|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616447|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA alternative polyadenylation|
|RNA N6-methyladenosine methyltransferase complex|
|mRNA methylation|
|regulation of mRNA polyadenylation|
|mRNA modification|
|regulation of mRNA 3-end processing|
|RNA methylation|
|regulation of mRNA processing|
|RNA modification|
|macromolecule methylation|
|nuclear body|
|methylation|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.16|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.94|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.8|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.78|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.7|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.82|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.97|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.1|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.24|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.465|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 388/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|21/28|
|bone|9/26|
|breast|16/33|
|central nervous system|29/56|
|cervix|1/4|
|colorectal|14/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|6/21|
|liver|11/20|
|lung|36/75|
|lymphocyte|9/16|
|ovary|13/26|
|pancreas|11/24|
|peripheral nervous system|10/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|16/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2369
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1429 Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>