KIAA1715 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA1715 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LNPK
  * **<color #00a2e8>Official Name</color>**: lunapark, ER junction formation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80856|80856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0E8|Q9C0E8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1715&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1715|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb and central nervous system development (By similarity). {ECO:0000250|UniProtKB:Q7TQ95, ECO:0000269|PubMed:24223779, ECO:0000269|PubMed:25404289, ECO:0000269|PubMed:25548161, ECO:0000269|PubMed:27619977}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2296|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum tubular network maintenance|
|positive regulation of endoplasmic reticulum tubular network organization|
|endoplasmic reticulum tubular network membrane|
|regulation of endoplasmic reticulum tubular network organization|
|endoplasmic reticulum tubular network organization|
|endoplasmic reticulum tubular network|
|embryonic forelimb morphogenesis|
|forelimb morphogenesis|
|cellular component maintenance|
|regulation of chondrocyte differentiation|
|endoplasmic reticulum organization|
|embryonic digit morphogenesis|
|regulation of cartilage development|
|integral component of endoplasmic reticulum membrane|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|limb morphogenesis|
|appendage morphogenesis|
|appendage development|
|limb development|
|blood coagulation|
|coagulation|
|hemostasis|
|endomembrane system organization|
|wound healing|
|regulation of body fluid levels|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of organelle organization|
|endoplasmic reticulum membrane|
|embryo development|
|endoplasmic reticulum|
|identical protein binding|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1715 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>