KIDINS220 [The Human Chemical-Genetic Interaction Map Project]

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======= KIDINS220 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIDINS220
  * **<color #00a2e8>Official Name</color>**: kinase D interacting substrate 220
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57498|57498]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULH0|Q9ULH0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIDINS220&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIDINS220|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KAP NTPase|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase regulator activity|
|nerve growth factor signaling pathway|
|neurotrophin signaling pathway|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|activation of MAPKK activity|
|dendrite morphogenesis|
|PDZ domain binding|
|dendrite development|
|late endosome|
|positive regulation of MAP kinase activity|
|positive regulation of neuron projection development|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of neuron differentiation|
|in utero embryonic development|
|positive regulation of cell projection organization|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cell morphogenesis involved in differentiation|
|positive regulation of kinase activity|
|protein-containing complex|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of kinase activity|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|regulation of transferase activity|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-3.04|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.5|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.43|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.29|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.29|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.17|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.16|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.15|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.14|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.14|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.13|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.01|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.99|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.94|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.92|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.9|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.86|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.85|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.84|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.78|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.78|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.76|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.75|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.85|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.89|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.92|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.1|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.11|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.23|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.78|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|7.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:x:xpr1|XPR1]]|0.73|
|[[:human genes:i:ip6k1|IP6K1]]|0.622|
|[[:human genes:i:ip6k2|IP6K2]]|0.584|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13657
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIDINS220 Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>