KIF14 [The Human Chemical-Genetic Interaction Map Project]

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======= KIF14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF14
  * **<color #00a2e8>Official Name</color>**: kinesin family member 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9928|9928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15058|Q15058]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611279|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). {ECO:0000250|UniProtKB:L0N7N1, ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480, ECO:0000269|PubMed:23209302, ECO:0000269|PubMed:24784001, ECO:0000269|PubMed:24854087}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar granular layer structural organization|
|cerebellar Purkinje cell layer structural organization|
|cerebellar cortex structural organization|
|negative regulation of integrin activation|
|regulation of Rap protein signal transduction|
|cerebellar granular layer morphogenesis|
|regulation of integrin activation|
|cerebellar granular layer development|
|cerebellar Purkinje cell layer morphogenesis|
|anatomical structure arrangement|
|microtubule depolymerization|
|regulation of cell maturation|
|cerebellar Purkinje cell layer development|
|spindle midzone|
|ATP-dependent microtubule motor activity, plus-end-directed|
|cell proliferation in forebrain|
|Flemming body|
|cerebellar cortex morphogenesis|
|olfactory bulb development|
|olfactory lobe development|
|protein depolymerization|
|cerebellum morphogenesis|
|positive regulation of cytokinesis|
|hindbrain morphogenesis|
|regulation of myelination|
|mitotic metaphase plate congression|
|cerebellar cortex development|
|microtubule polymerization or depolymerization|
|substrate adhesion-dependent cell spreading|
|kinesin complex|
|tubulin binding|
|metaphase plate congression|
|microtubule motor activity|
|establishment of chromosome localization|
|chromosome localization|
|neural precursor cell proliferation|
|hippocampus development|
|positive regulation of cell division|
|PDZ domain binding|
|regulation of cytokinesis|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|cerebellum development|
|mitotic sister chromatid segregation|
|limbic system development|
|metencephalon development|
|cerebral cortex development|
|negative regulation of protein complex assembly|
|cellular protein complex disassembly|
|sister chromatid segregation|
|negative regulation of neuron apoptotic process|
|mitotic nuclear division|
|regulation of G1/S transition of mitotic cell cycle|
|hindbrain development|
|midbody|
|regulation of cell cycle G1/S phase transition|
|regulation of cell division|
|pallium development|
|cell-substrate adhesion|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of cell cycle G2/M phase transition|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|protein-containing complex disassembly|
|regulation of Ras protein signal transduction|
|telencephalon development|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|regulation of neuron death|
|organelle fission|
|microtubule|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|activation of protein kinase activity|
|regulation of small GTPase mediated signal transduction|
|proteasomal protein catabolic process|
|establishment of organelle localization|
|positive regulation of cell cycle|
|forebrain development|
|cellular component disassembly|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|positive regulation of kinase activity|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|regulation of growth|
|microtubule-based process|
|regulation of cell adhesion|
|protein catabolic process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|cell morphogenesis|
|brain development|
|regulation of cell cycle process|
|head development|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of protein phosphorylation|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chromosome organization|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|proteolysis|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.88|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.71|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.8|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hspd1|HSPD1]]|0.433|
|[[:human genes:r:rnmt|RNMT]]|0.423|
|[[:human genes:a:adsl|ADSL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|4/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2621
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF14 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>