KIF20A [The Human Chemical-Genetic Interaction Map Project]

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======= KIF20A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF20A
  * **<color #00a2e8>Official Name</color>**: kinesin family member 20A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10112|10112]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95235|O95235]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF20A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF20A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605664|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|midbody abscission|
|mitotic cytokinetic process|
|cytokinetic process|
|transporter activity|
|kinesin complex|
|cleavage furrow|
|intercellular bridge|
|microtubule motor activity|
|mitotic cytokinesis|
|regulation of cytokinesis|
|microtubule bundle formation|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|spindle|
|midbody|
|regulation of cell division|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|microtubule|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|membrane organization|
|Golgi apparatus|
|cell cycle process|
|cytoskeleton organization|
|regulation of cell cycle|
|cell cycle|
|ATP binding|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-4.1|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-3.05|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.24|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.01|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.97|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.92|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.84|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2s|UBE2S]]|0.465|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13280
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF20A Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>