KIF23 [The Human Chemical-Genetic Interaction Map Project]

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======= KIF23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF23
  * **<color #00a2e8>Official Name</color>**: kinesin family member 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9493|9493]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02241|Q02241]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605064|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centralspindlin complex|
|assembly of actomyosin apparatus involved in cytokinesis|
|actomyosin contractile ring assembly|
|actomyosin contractile ring organization|
|mitotic spindle midzone assembly|
|plus-end-directed vesicle transport along microtubule|
|plus-end-directed organelle transport along microtubule|
|mitotic spindle elongation|
|spindle elongation|
|spindle midzone assembly|
|Flemming body|
|cytokinetic process|
|mitotic spindle assembly|
|positive regulation of cytokinesis|
|cortical actin cytoskeleton organization|
|vesicle transport along microtubule|
|cortical cytoskeleton organization|
|vesicle cytoskeletal trafficking|
|kinesin complex|
|intercellular bridge|
|microtubule motor activity|
|mitotic cytokinesis|
|mitotic spindle organization|
|mitotic spindle|
|organelle transport along microtubule|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|positive regulation of cell division|
|regulation of cytokinesis|
|cytoskeleton-dependent cytokinesis|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|cytokinesis|
|antigen processing and presentation of peptide antigen via MHC class II|
|spindle assembly|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|actomyosin structure organization|
|spindle|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|transport along microtubule|
|midbody|
|regulation of cell division|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|microtubule|
|establishment of organelle localization|
|Golgi vesicle transport|
|positive regulation of cell cycle|
|focal adhesion|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|actin cytoskeleton organization|
|actin filament-based process|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|cell cycle|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-2.7|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.01|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.01|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.99|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.98|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.96|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.89|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.76|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.75|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.7|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.76|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.82|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.86|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.87|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.98|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 697/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|20/26|
|breast|31/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|19/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1409
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF23 Expression in NALM6 Cells: 7.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>