KIF2A [The Human Chemical-Genetic Interaction Map Project]

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======= KIF2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF2A
  * **<color #00a2e8>Official Name</color>**: kinesin family member 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3796|3796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00139|O00139]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602591|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269|PubMed:15843429, ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:18411309}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centriolar subdistal appendage|
|microtubule depolymerization|
|sperm principal piece|
|protein depolymerization|
|mitotic spindle assembly|
|spindle microtubule|
|motor activity|
|microtubule polymerization or depolymerization|
|kinesin complex|
|microtubule motor activity|
|mitotic spindle organization|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|spindle assembly|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|microtubule cytoskeleton organization involved in mitosis|
|spindle pole|
|cellular protein complex disassembly|
|centriole|
|mitotic nuclear division|
|spindle organization|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|ATPase activity|
|microtubule binding|
|protein-containing complex disassembly|
|microtubule-based movement|
|nuclear body|
|nuclear division|
|organelle fission|
|microtubule|
|Golgi vesicle transport|
|cellular component disassembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|regulation of cell migration|
|nucleolus|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|ATP binding|
|movement of cell or subcellular component|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-4.04|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-3.4|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-3.27|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-3.24|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-3.22|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.89|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.35|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.21|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2.09|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.06|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.05|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.01|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.98|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.94|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.94|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.91|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.86|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.85|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.81|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.81|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.73|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.71|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.89|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.01|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.08|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.15|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.22|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.6|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|3.25|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:katna1|KATNA1]]|0.484|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7825
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF2A Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>