KIF4A [The Human Chemical-Genetic Interaction Map Project]

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======= KIF4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF4A
  * **<color #00a2e8>Official Name</color>**: kinesin family member 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=24137|24137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95239|O95239]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic spindle midzone assembly|
|mitotic spindle elongation|
|spindle elongation|
|spindle midzone assembly|
|spindle microtubule|
|mitotic spindle assembly|
|anterograde axonal transport|
|kinesin complex|
|axonal transport|
|axon cytoplasm|
|intercellular bridge|
|axo-dendritic transport|
|microtubule motor activity|
|mitotic cytokinesis|
|mitotic spindle organization|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|cytoskeleton-dependent cytokinesis|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|cytokinesis|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|spindle assembly|
|antigen processing and presentation of peptide antigen via MHC class II|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|nuclear matrix|
|chromosome|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|transport along microtubule|
|midbody|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule|
|Golgi vesicle transport|
|microtubule cytoskeleton organization|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|DNA binding|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.78|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-3.14|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.69|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.26|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.2|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.04|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.03|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.93|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.78|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.72|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.74|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.8|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.88|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.99|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.32|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.51|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kif18b|KIF18B]]|0.494|
|[[:human genes:c:clasp2|CLASP2]]|0.437|
|[[:human genes:k:kif2c|KIF2C]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 190/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|9/26|
|bone|4/26|
|breast|8/30|
|central nervous system|14/49|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/11|
|fibroblast|0/1|
|gastric|4/14|
|kidney|9/18|
|liver|5/19|
|lung|15/72|
|lymphocyte|2/16|
|ovary|9/25|
|pancreas|9/22|
|peripheral nervous system|4/15|
|plasma cell|6/12|
|prostate|0/1|
|skin|5/20|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|5/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF4A Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>