KIF5A [The Human Chemical-Genetic Interaction Map Project]

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======= KIF5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF5A
  * **<color #00a2e8>Official Name</color>**: kinesin family member 5A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3798|3798]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12840|Q12840]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602821|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. {ECO:0000250|UniProtKB:P33175}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anterograde dendritic transport of neurotransmitter receptor complex|
|retrograde neuronal dense core vesicle transport|
|anterograde dendritic transport|
|dense core granule transport|
|dense core granule cytoskeletal transport|
|dense core granule localization|
|anterograde axonal protein transport|
|dendritic transport|
|protein localization to presynapse|
|ciliary rootlet|
|secretory granule localization|
|axo-dendritic protein transport|
|retrograde axonal transport|
|ATP-dependent microtubule motor activity, plus-end-directed|
|dendrite cytoplasm|
|neurotransmitter receptor transport|
|synaptic vesicle transport|
|synaptic vesicle localization|
|receptor localization to synapse|
|kinesin binding|
|anterograde axonal transport|
|vesicle transport along microtubule|
|motor activity|
|vesicle cytoskeletal trafficking|
|kinesin complex|
|axonal transport|
|axon cytoplasm|
|protein localization to synapse|
|axo-dendritic transport|
|microtubule motor activity|
|protein transport along microtubule|
|microtubule-based protein transport|
|organelle transport along microtubule|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|cytosolic transport|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|ATPase activity|
|microtubule binding|
|protein-containing complex localization|
|axon guidance|
|neuron projection guidance|
|microtubule-based movement|
|microtubule|
|establishment of organelle localization|
|neuronal cell body|
|axonogenesis|
|Golgi vesicle transport|
|axon development|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|organelle localization|
|neuron projection development|
|microtubule-based process|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|intracellular protein transport|
|neuron differentiation|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.91|
|[[:results:exp453|B02 10μM R08 exp453]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF5A Expression in NALM6 Cells: -0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>