KIFAP3 [The Human Chemical-Genetic Interaction Map Project]

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======= KIFAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIFAP3
  * **<color #00a2e8>Official Name</color>**: kinesin associated protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22920|22920]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92845|Q92845]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIFAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIFAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcium-dependent cell-cell adhesion|
|regulation of calcium-dependent cell-cell adhesion|
|kinesin II complex|
|intraciliary transport particle B binding|
|periciliary membrane compartment|
|plus-end-directed vesicle transport along microtubule|
|plus-end-directed organelle transport along microtubule|
|condensed nuclear chromosome|
|spindle microtubule|
|photoreceptor connecting cilium|
|intraciliary transport involved in cilium assembly|
|kinesin binding|
|vesicle transport along microtubule|
|ciliary tip|
|vesicle cytoskeletal trafficking|
|intraciliary transport|
|protein transport along microtubule|
|microtubule-based protein transport|
|organelle transport along microtubule|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|protein phosphatase binding|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|axoneme|
|ciliary basal body|
|microtubule cytoskeleton|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|cilium|
|antigen processing and presentation|
|positive regulation of cell-cell adhesion|
|protein-containing complex localization|
|microtubule-based movement|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|Golgi vesicle transport|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|organelle localization|
|microtubule-based process|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|organelle assembly|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|Golgi apparatus|
|negative regulation of cell death|
|intracellular protein transport|
|endoplasmic reticulum|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of cell death|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIFAP3 Expression in NALM6 Cells: 3.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>