KIFC1 [The Human Chemical-Genetic Interaction Map Project]

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======= KIFC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIFC1
  * **<color #00a2e8>Official Name</color>**: kinesin family member C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3833|3833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BW19|Q9BW19]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIFC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIFC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9QWT9, ECO:0000269|PubMed:15843429}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin tail 1|
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic spindle assembly|
|mitotic metaphase plate congression|
|kinesin complex|
|metaphase plate congression|
|microtubule motor activity|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle organization|
|mitotic spindle|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|spindle organization|
|microtubule organizing center|
|nuclear chromosome segregation|
|ATPase activity|
|microtubule binding|
|early endosome|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule|
|establishment of organelle localization|
|microtubule cytoskeleton organization|
|cell division|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|movement of cell or subcellular component|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.3|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.89|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.54|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.39|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.1|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.76|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.7|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.03|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.12|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.26|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.42|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.88|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.97|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|6.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vbp1|VBP1]]|0.445|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6643
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIFC1 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>