KITLG [The Human Chemical-Genetic Interaction Map Project]

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======= KITLG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KITLG
  * **<color #00a2e8>Official Name</color>**: KIT ligand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4254|4254]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21583|P21583]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KITLG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KITLG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/184745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SCF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mast cell proliferation|
|negative regulation of mast cell apoptotic process|
|regulation of mast cell proliferation|
|regulation of mast cell apoptotic process|
|stem cell factor receptor binding|
|positive regulation of hematopoietic stem cell proliferation|
|positive regulation of melanocyte differentiation|
|positive regulation of hematopoietic progenitor cell differentiation|
|regulation of melanocyte differentiation|
|ectopic germ cell programmed cell death|
|positive regulation of pigment cell differentiation|
|regulation of hematopoietic stem cell proliferation|
|regulation of pigment cell differentiation|
|positive regulation of developmental pigmentation|
|programmed cell death involved in cell development|
|regulation of developmental pigmentation|
|negative regulation of myeloid cell apoptotic process|
|embryonic hemopoiesis|
|regulation of myeloid cell apoptotic process|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|positive regulation of stem cell proliferation|
|negative regulation of leukocyte apoptotic process|
|ovarian follicle development|
|positive regulation of myeloid leukocyte differentiation|
|neural crest cell migration|
|positive regulation of Ras protein signal transduction|
|regulation of stem cell proliferation|
|positive regulation of small GTPase mediated signal transduction|
|filopodium|
|neural crest cell development|
|regulation of leukocyte apoptotic process|
|mesenchymal cell development|
|stem cell development|
|regulation of hematopoietic progenitor cell differentiation|
|female gonad development|
|neural crest cell differentiation|
|positive regulation of myeloid cell differentiation|
|development of primary female sexual characteristics|
|extrinsic apoptotic signaling pathway|
|female sex differentiation|
|regulation of myeloid leukocyte differentiation|
|positive regulation of leukocyte migration|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of leukocyte proliferation|
|positive regulation of leukocyte differentiation|
|mesenchymal cell differentiation|
|male sex differentiation|
|stem cell differentiation|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|ameboidal-type cell migration|
|cytokine activity|
|lamellipodium|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte migration|
|gonad development|
|development of primary sexual characteristics|
|regulation of protein kinase B signaling|
|mesenchyme development|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|regulation of Ras protein signal transduction|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|sex differentiation|
|regulation of leukocyte differentiation|
|apoptotic signaling pathway|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|hemopoiesis|
|positive regulation of kinase activity|
|hematopoietic or lymphoid organ development|
|immune system development|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14401
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KITLG Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>