KLHL10 [The Human Chemical-Genetic Interaction Map Project]

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======= KLHL10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLHL10
  * **<color #00a2e8>Official Name</color>**: kelch like family member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=317719|317719]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6JEL2|Q6JEL2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLHL10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLHL10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608778|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
|Kelch 1|
|Kelch 2|
|BACK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|male anatomical structure morphogenesis|
|male genitalia morphogenesis|
|genitalia morphogenesis|
|male genitalia development|
|homeostasis of number of cells within a tissue|
|genitalia development|
|male gonad development|
|development of primary male sexual characteristics|
|spermatid development|
|spermatid differentiation|
|male sex differentiation|
|fertilization|
|tissue homeostasis|
|homeostasis of number of cells|
|gonad development|
|development of primary sexual characteristics|
|germ cell development|
|sex differentiation|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|cellular process involved in reproduction in multicellular organism|
|reproductive structure development|
|reproductive system development|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|protein ubiquitination|
|gamete generation|
|cell morphogenesis|
|protein modification by small protein conjugation|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|animal organ morphogenesis|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|homeostatic process|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.78|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.546|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLHL10 Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>