KLHL41 [The Human Chemical-Genetic Interaction Map Project]

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======= KLHL41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLHL41
  * **<color #00a2e8>Official Name</color>**: kelch like family member 41
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10324|10324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60662|O60662]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLHL41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLHL41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607701|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. {ECO:0000250|UniProtKB:A2AUC9}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BACK|
|BTB|
|Kelch 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of lateral pseudopodium assembly|
|regulation of myoblast proliferation|
|regulation of pseudopodium assembly|
|pseudopodium|
|regulation of skeletal muscle cell differentiation|
|skeletal muscle fiber development|
|myotube cell development|
|M band|
|sarcoplasmic reticulum membrane|
|Cul3-RING ubiquitin ligase complex|
|sarcomere organization|
|regulation of skeletal muscle tissue development|
|skeletal muscle cell differentiation|
|regulation of myoblast differentiation|
|myotube differentiation|
|muscle fiber development|
|myofibril assembly|
|ruffle|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actomyosin structure organization|
|skeletal muscle tissue development|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle tissue development|
|striated muscle cell development|
|regulation of muscle organ development|
|muscle cell development|
|regulation of plasma membrane bounded cell projection assembly|
|striated muscle cell differentiation|
|regulation of cell projection assembly|
|muscle cell differentiation|
|muscle contraction|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|post-translational protein modification|
|cytoskeleton|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|actin filament-based process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|organelle assembly|
|protein modification by small protein conjugation|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|cytoskeleton organization|
|regulation of cell population proliferation|
|cell development|
|tissue development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.12|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.72|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.74|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.75|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.99|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.05|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.09|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.18|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLHL41 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>