KMT2B [The Human Chemical-Genetic Interaction Map Project]

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======= KMT2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KMT2B
  * **<color #00a2e8>Official Name</color>**: lysine methyltransferase 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9757|9757]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UMN6|Q9UMN6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KMT2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KMT2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation. {ECO:0000269|PubMed:17707229}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FYRC|
|FYRN|
|SET|
|PHD|
|zf-CXXC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin-mediated maintenance of transcription|
|histone H3-K4 trimethylation|
|histone methyltransferase activity (H3-K4 specific)|
|ovulation|
|regulation of histone H3-K4 methylation|
|peptidyl-lysine trimethylation|
|histone H3-K4 methylation|
|histone methyltransferase complex|
|oocyte differentiation|
|ovarian follicle development|
|regulation of megakaryocyte differentiation|
|positive regulation of gene expression, epigenetic|
|regulation of histone methylation|
|chromatin organization involved in regulation of transcription|
|histone lysine methylation|
|oogenesis|
|female gonad development|
|peptidyl-lysine methylation|
|histone methylation|
|development of primary female sexual characteristics|
|female sex differentiation|
|memory|
|female gamete generation|
|protein methylation|
|protein alkylation|
|regulation of histone modification|
|gene silencing|
|regulation of chromatin organization|
|gonad development|
|development of primary sexual characteristics|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|macromolecule methylation|
|germ cell development|
|learning or memory|
|sex differentiation|
|cognition|
|methylation|
|peptidyl-lysine modification|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|histone modification|
|covalent chromatin modification|
|reproductive structure development|
|reproductive system development|
|regulation of hemopoiesis|
|behavior|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|gamete generation|
|chromatin organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|multi-organism reproductive process|
|chromosome organization|
|regulation of organelle organization|
|nervous system process|
|reproductive process|
|reproduction|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.02|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.93|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.91|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.87|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.77|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.73|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.72|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.74|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.91|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.94|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.98|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.07|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.07|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.19|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.27|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1668
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KMT2B Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>