KPNA3 [The Human Chemical-Genetic Interaction Map Project]

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======= KPNA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KPNA3
  * **<color #00a2e8>Official Name</color>**: karyopherin subunit alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3839|3839]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00505|O00505]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KPNA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KPNA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBB|
|Arm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral penetration into host nucleus|
|multi-organism nuclear import|
|multi-organism intracellular transport|
|multi-organism cellular localization|
|NLS-bearing protein import into nucleus|
|modulation by virus of host cellular process|
|nuclear import signal receptor activity|
|nuclear localization sequence binding|
|modulation by symbiont of host cellular process|
|modulation by virus of host morphology or physiology|
|modification by symbiont of host morphology or physiology|
|intracellular transport of virus|
|host cell|
|transport of virus|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|viral entry into host cell|
|protein import into nucleus|
|entry into host cell|
|entry into host|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|import into nucleus|
|protein import|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein localization to nucleus|
|protein C-terminus binding|
|viral life cycle|
|nucleocytoplasmic transport|
|nuclear transport|
|establishment of protein localization to organelle|
|viral process|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.13|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.83|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.8|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.41|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.21|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.17|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.11|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.07|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.06|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.05|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.99|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.98|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.97|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.89|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.86|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.86|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.81|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.8|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.76|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.74|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kpna4|KPNA4]]|0.555|
|[[:human genes:g:gtpbp2|GTPBP2]]|0.489|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.475|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5655
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KPNA3 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>