KPNA4 [The Human Chemical-Genetic Interaction Map Project]

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======= KPNA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KPNA4
  * **<color #00a2e8>Official Name</color>**: karyopherin subunit alpha 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3840|3840]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00629|O00629]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KPNA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KPNA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arm|
|IBB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NLS-bearing protein import into nucleus|
|modulation by virus of host cellular process|
|nuclear import signal receptor activity|
|modulation by symbiont of host cellular process|
|modulation by virus of host morphology or physiology|
|modification by symbiont of host morphology or physiology|
|protein import into nucleus|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|import into nucleus|
|response to hydrogen peroxide|
|protein import|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein localization to nucleus|
|response to reactive oxygen species|
|nuclear membrane|
|nucleocytoplasmic transport|
|nuclear transport|
|response to antibiotic|
|response to oxidative stress|
|establishment of protein localization to organelle|
|response to toxic substance|
|response to inorganic substance|
|viral process|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|intracellular protein transport|
|response to drug|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.45|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-3.37|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-3.26|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.77|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.77|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.68|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.65|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.61|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.48|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.39|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.21|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.02|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.02|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.88|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.87|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.79|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.77|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.76|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.74|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.7|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kpna3|KPNA3]]|0.555|
|[[:human genes:g:gtpbp2|GTPBP2]]|0.534|
|[[:human genes:r:rnaseh2a|RNASEH2A]]|0.508|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.489|
|[[:human genes:r:rad17|RAD17]]|0.431|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.416|
|[[:human genes:r:rbm15|RBM15]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4252
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KPNA4 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>