KRT17 [The Human Chemical-Genetic Interaction Map Project]

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======= KRT17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT17
  * **<color #00a2e8>Official Name</color>**: keratin 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3872|3872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04695|Q04695]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/148069|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MHC class II protein binding|
|MHC class II receptor activity|
|positive regulation of hair follicle development|
|positive regulation of hair cycle|
|regulation of hair follicle development|
|intermediate filament organization|
|hair follicle morphogenesis|
|regulation of hair cycle|
|epidermis morphogenesis|
|cell periphery|
|positive regulation of epidermis development|
|intermediate filament cytoskeleton|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|regulation of epidermis development|
|hair cycle|
|molting cycle|
|structural constituent of cytoskeleton|
|cornification|
|intermediate filament|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|positive regulation of cell growth|
|keratinization|
|positive regulation of growth|
|keratinocyte differentiation|
|epidermal cell differentiation|
|regulation of translation|
|skin development|
|regulation of cellular amide metabolic process|
|epidermis development|
|regulation of cell growth|
|morphogenesis of an epithelium|
|supramolecular fiber organization|
|posttranscriptional regulation of gene expression|
|tissue morphogenesis|
|regulation of growth|
|epithelial cell differentiation|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|epithelium development|
|positive regulation of developmental process|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT17 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>