KRTAP10-6 [The Human Chemical-Genetic Interaction Map Project]

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======= KRTAP10-6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRTAP10-6
  * **<color #00a2e8>Official Name</color>**: keratin associated protein 10-6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=386674|386674]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60371|P60371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRTAP10-6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRTAP10-6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|keratin filament|
|keratinization|
|keratinocyte differentiation|
|epidermal cell differentiation|
|skin development|
|epidermis development|
|epithelial cell differentiation|
|epithelium development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.12|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.95|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.93|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.77|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.7|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.71|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.73|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.73|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.74|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.74|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.8|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.8|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.87|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.87|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.94|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.94|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.06|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.26|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.36|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRTAP10-6 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>